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Severe Hypoglycemia: Recognizing the Emergency and What to Do Next
17 Sep 2025 By Eleanna O. De Filippis, M.D., Ph.D.

Severe Hypoglycemia: Recognizing the Emergency and What to Do Next

Severe hypoglycemia, or dangerously low blood sugar, is a critical condition that demands immediate attention. Understanding the signs, symptoms, and appropriate responses can be life-saving for individuals with diabetes or those susceptible to blood sugar imbalances. This article aims to equip you with the knowledge to recognize severe hypoglycemia and take effective steps to manage the situation promptly.

What is Severe Hypoglycemia?

Hypoglycemia occurs when the level of glucose (sugar) in the blood drops too low, typically below 70 mg/dL (3.9 mmol/L). Severe hypoglycemia is a more extreme form, often defined as a state where the individual is unable to treat themselves and requires assistance from another person. This level of hypoglycemia can lead to confusion, seizures, loss of consciousness, and if untreated, can be fatal.

Why Does Severe Hypoglycemia Happen?

Severe hypoglycemia can occur for various reasons, most commonly in individuals managing diabetes with insulin or certain oral medications. Key factors include:

  • Excessive Insulin Dosage: Taking too much insulin compared to food intake or activity level.
  • Skipped or Delayed Meals: Not consuming enough carbohydrates, especially after taking diabetes medications.
  • Intense Physical Activity: Strenuous exercise without adequate carbohydrate replenishment.
  • Alcohol Consumption: Alcohol can impair the liver's ability to release glucose, leading to hypoglycemia, particularly when consumed on an empty stomach.
  • Kidney or Liver Issues: Impaired kidney or liver function can affect glucose metabolism and medication clearance.
  • Other Medical Conditions: Certain medical conditions can influence blood sugar levels.
  • Medication Interactions: Some medications can interfere with blood glucose control.

Understanding these potential causes is essential for preventing severe hypoglycemia by making informed decisions about medication, diet, and lifestyle.

Recognizing the Signs and Symptoms of Severe Hypoglycemia

Identifying the signs of severe hypoglycemia quickly is crucial for timely intervention. Symptoms vary from person to person, but some common indicators include: Blood Sugar And Weight Loss The Definitive Connection You Need To Know

  • Confusion or Disorientation: Difficulty thinking clearly, confusion, or being disoriented.
  • Seizures: Uncontrolled muscle spasms and loss of awareness.
  • Loss of Consciousness: Unresponsiveness to stimuli, inability to wake up.
  • Weakness or Coordination Problems: Extreme weakness, difficulty walking, or maintaining balance.
  • Slurred Speech: Difficulty speaking clearly, sounding like being intoxicated.
  • Aggression or Irritability: Sudden mood changes, becoming unusually aggressive or irritable.
  • Pale Skin: Loss of color in the skin, appearing unusually pale.
  • Sweating: Profuse sweating, even in a cool environment.
  • Rapid Heartbeat: An elevated heart rate, feeling like the heart is racing.

Recognizing these symptoms—particularly in someone with diabetes or known to be at risk—is the first step toward preventing serious consequences.

What to Do in Case of Severe Hypoglycemia

If you suspect someone is experiencing severe hypoglycemia, here's a step-by-step guide on how to respond:

  1. Assess the Situation:

    • Check for Responsiveness: Gently try to wake the person and see if they respond to verbal or tactile stimuli.
    • Look for Medical Identification: Check for a medical ID bracelet, necklace, or wallet card indicating they have diabetes.
  2. If the Person is Conscious and Able to Swallow:

    • Administer Fast-Acting Carbohydrates:
      • Give them a source of fast-acting carbohydrates such as:
        • Glucose Tablets: Typically 3-4 tablets (check the label for carbohydrate content, aim for 15-20 grams).
        • Glucose Gel: Apply glucose gel inside their cheek.
        • Fruit Juice or Regular Soda: 4 ounces (120 ml) of juice or regular (not diet) soda.
        • Hard Candies: 4-5 hard candies (avoid sugar-free).
        • Honey or Syrup: 1 tablespoon.
    • Wait 15 Minutes:
      • After administering carbohydrates, wait 15 minutes.
      • Recheck Blood Sugar: If possible, check their blood sugar levels using a glucometer.
    • Repeat if Necessary:
      • If the person still shows symptoms or their blood sugar remains below 70 mg/dL, repeat the fast-acting carbohydrate treatment.
      • Continue this process until their condition improves.
    • Follow with a Longer-Acting Carbohydrate:
      • Once the immediate symptoms subside, provide a snack containing both carbohydrates and protein to stabilize blood sugar levels, such as:
        • Crackers with Peanut Butter
        • Cheese and Fruit
        • A Small Sandwich
  3. If the Person is Unconscious or Unable to Swallow:

    • Do NOT Attempt to Give Food or Drink:
      • It's crucial not to force food or liquid into an unconscious person, as this can cause choking.
    • Administer Glucagon (If Available and Trained):
      • Glucagon is a hormone that raises blood sugar levels. It's available as an injectable or nasal spray and is typically prescribed to individuals at risk of severe hypoglycemia.
      • Injectable Glucagon: Follow the instructions provided with the glucagon kit. Typically, this involves mixing the glucagon powder with the diluent, then injecting it into the muscle (e.g., thigh or arm).
      • Nasal Glucagon: Follow the directions for administering the nasal spray, which is typically a single dose sprayed into one nostril.
      • Ensure Proper Training: It’s vital that family members, friends, or caregivers know how to administer glucagon correctly through a demonstration and education by a medical professional.
    • Call for Emergency Medical Assistance (911 or Local Equivalent):
      • Even if you administer glucagon and the person regains consciousness, it's essential to call emergency services immediately. Glucagon's effects are temporary, and the person needs professional medical evaluation and care.
      • Provide clear information to the emergency responders: the person's condition, known medical history (diabetes), treatments administered, and any other relevant details.
  4. Stay with the Person Until Help Arrives:

    • Monitor Breathing and Vital Signs: Keep a close watch on their breathing and overall condition. Be prepared to provide basic first aid if necessary.
    • Provide Reassurance: If the person regains consciousness, reassure them and keep them calm while waiting for medical assistance.

Example Scenario:

Imagine you are at a family gathering, and your uncle, who has diabetes, suddenly becomes confused, starts sweating profusely, and is having difficulty speaking. You suspect severe hypoglycemia.

Steps to take:

  1. Check responsiveness: You try to speak to him, but he doesn't respond coherently.
  2. Administer fast-acting carbs if conscious: Since he is able to swallow, you give him 4 glucose tablets.
  3. Wait and recheck: After 15 minutes, he is still confused. You give him another set of glucose tablets.
  4. Monitor & Follow up: After another 15 minutes, his condition improves and he becomes more alert. You give him crackers with peanut butter.
  5. If the person is unconscious, use glucagon (if available) and call 911.

Preventing Future Episodes of Severe Hypoglycemia

Prevention is key to avoiding the risks associated with severe hypoglycemia. Individuals with diabetes and their caregivers should implement the following strategies:

  • Regular Blood Glucose Monitoring:

    • Frequent Checks: Consistently monitor blood glucose levels, especially before meals, after meals, before bedtime, and before and after exercise.
    • Use a Continuous Glucose Monitor (CGM): Consider using a CGM, which provides real-time glucose readings and alerts for high or low levels.
  • Meal Planning and Timing:

    • Consistent Meal Schedules: Eat meals and snacks at regular times each day.
    • Carbohydrate Counting: Understand how different foods affect blood sugar levels and learn to count carbohydrates accurately.
    • Balancing Meals: Ensure meals contain an appropriate balance of carbohydrates, proteins, and fats.
  • Medication Management:

    • Adherence to Prescribed Dosages: Take diabetes medications exactly as prescribed by your healthcare provider.
    • Coordination with Healthcare Team: Regularly review medication regimens with your healthcare provider, especially when making changes to diet, exercise, or other medications.
    • Insulin Adjustment Based on Activity: Adjust insulin dosages based on physical activity levels, following guidance from your healthcare provider.
  • Education and Training:

    • Patient Education Programs: Participate in diabetes education programs to learn about managing blood sugar levels, recognizing hypoglycemia, and administering glucagon.
    • Family and Caregiver Training: Ensure family members, friends, and caregivers are trained to recognize and respond to severe hypoglycemia, including glucagon administration.
  • Awareness of Alcohol Consumption:

    • Moderation: Consume alcohol in moderation, if at all, and always with food.
    • Monitor Blood Sugar: Check blood sugar levels more frequently when consuming alcohol, as it can lower blood sugar hours later.
  • Carry Medical Identification:

    • Wear a Medical ID: Wear a medical identification bracelet or necklace that indicates having diabetes and any other relevant medical conditions.
    • Carry Information: Carry a wallet card with information about diabetes, medications, emergency contacts, and healthcare provider information.

By integrating these strategies into daily life, individuals can significantly reduce their risk of experiencing severe hypoglycemia and maintain better overall health. Can You Lower Your A1C Blood Sugar Naturally Diet Amp Lifestyle Tips

The Importance of Glucagon

Glucagon is a critical medication designed to rapidly increase blood glucose levels in individuals experiencing severe hypoglycemia. It is often prescribed to those at risk of significant drops in blood sugar, such as people with insulin-dependent diabetes. Understanding how to use glucagon is essential for preventing severe outcomes like seizures, coma, or even death.

How Glucagon Works

Glucagon works by stimulating the liver to release stored glucose into the bloodstream. This action raises the blood sugar level, helping to revive someone experiencing severe hypoglycemia.

Who Should Have Glucagon?

  • Individuals with Type 1 Diabetes: Especially those prone to frequent or severe hypoglycemia.
  • Individuals with Type 2 Diabetes: Those taking insulin or other medications that can cause hypoglycemia.
  • Children with Diabetes: Due to the difficulty in recognizing hypoglycemia symptoms in young children.

Types of Glucagon Kits

  1. Injectable Glucagon:

    • Description: The traditional form consists of a vial of powdered glucagon and a syringe filled with sterile diluent.
    • Preparation: Requires mixing the powder and liquid before injection.
    • Administration: Injected into the muscle (usually in the thigh, arm, or buttocks).
    • Nasal Glucagon (Baqsimi):

    • Description: A pre-filled, single-dose nasal spray.

    • Preparation: No mixing required; ready to use.
    • Administration: Sprayed into one nostril. No need to inhale.

Administering Glucagon: Step-by-Step

It’s crucial for family members and caregivers to be properly trained on how to administer glucagon.

Injectable Glucagon:

  1. Prepare the Injection:

    • Remove the caps from the glucagon vial and the diluent syringe.
    • Inject the diluent into the glucagon vial.
    • Gently roll the vial between your hands until the glucagon is completely dissolved.
    • Draw Up the Dose:

    • Insert the syringe into the vial.

    • Draw up the prescribed dose (usually 1 mg for adults, half for children).
    • Inject the Glucagon:

    • Choose an injection site (thigh, arm, or buttocks).

    • Clean the area with an alcohol swab.
    • Pinch the skin and insert the needle at a 90-degree angle.
    • Push the plunger to inject the glucagon.
    • Remove the needle and apply gentle pressure to the injection site.

Nasal Glucagon (Baqsimi):

  1. Prepare the Device:

    • Remove the device from its packaging.
    • Do not prime or test the device before use.
    • Administer the Dose:

    • Hold the device between your fingers and thumb.

    • Insert the nozzle into one nostril.
    • Press the plunger firmly to release the dose.
    • The medication does not require inhalation.

What to Expect After Glucagon Administration

  • Response Time: It may take 5 to 15 minutes for the person to regain consciousness.
  • Potential Side Effects: Common side effects include nausea and vomiting. Turn the person on their side to prevent choking if they vomit.
  • Continued Monitoring: Even after regaining consciousness, monitor the person closely. The effects of glucagon are temporary.
  • Seek Medical Attention: Always call emergency services (911 or your local emergency number) after administering glucagon. The person needs further evaluation and treatment.

Important Considerations

  • Training: Ensure all family members, caregivers, and close contacts are trained by a healthcare professional on how to recognize severe hypoglycemia and administer glucagon.
  • Storage: Store glucagon kits in an easily accessible location and check the expiration date regularly.
  • Prescription: Glucagon requires a prescription and should be kept on hand by individuals at risk of severe hypoglycemia.
  • Communicate: Inform friends, coworkers, and school staff about the possibility of hypoglycemia and where the glucagon kit is located.

By being prepared and knowing how to use glucagon, you can effectively manage severe hypoglycemia and prevent serious health consequences.

Conclusion

Recognizing and responding swiftly to severe hypoglycemia is critical for averting serious health risks. By understanding the causes, symptoms, and appropriate actions, individuals with diabetes, their families, and caregivers can confidently manage this emergency situation. Regular monitoring, medication management, and proactive planning are essential for prevention, while immediate intervention with fast-acting carbohydrates or glucagon can save lives. This knowledge empowers you to protect yourself and those around you from the potentially devastating effects of severe hypoglycemia. Essential Foods For Better Control Of Blood Glucose Levels

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