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This video reviews the new use of the drug semalgutide (Wegovy) for the treatment of weight loss in obese and overweight individuals. Semaglutide is given as a once a week injection under the skin. Semaglutide is also known by the brand name Ozempic which is used for Type 2 diabetes. Semaglutide is an injectable glucagon-like peptide-1 (GLP-1) receptor agonist. It acts as an incretin hormone that plays a role in appetite, digestion, gastric emptying, and satiety. Dosage should be slowly titrated upward to avoid gastrointestinal side effects. Instructions on how to administer the drug via a pen device will be covered. Semaglutide should not be used by anyone with a family history of thyroid cancer. In clinical studies, semaglutide resulted in a 15% decrease in body weight from baseline. The drug is expensive, with a monthly cost of $1300.